Hyaluronic Acid and Microneedling Duo

What Is Hyaluronic Acid?

Skin aging is generally linked to dryness and a decrease in skin elasticity. Hyaluronic acid (HA) is a natural substance found in the skin, and about 50% of the body's HA is in the dermis, the deeper layer of the skin. HA helps organize the skin structure and reduces the appearance of wrinkles. It does this because HA can hold a lot of water, which helps keep the skin firm and hydrated.

As we age, the amount of hyaluronic acid in our skin decreases. Fortunately, since HA is safe, biocompatible, and biodegradable, it is ideal for use in skincare and dermatology and can be added to the skin through skincare products. It draws water into the skin and holds it there, helping to maintain moisture levels.

 

 

Topical Hyaluronic Acid vs. Internal Hyaluronic Acid

While hyaluronic acid is naturally present in the body, it can also be taken in through topical products like serums or creams to target specific skin concerns.

Unfortunately, these topical HA-based products have low absorption rates and also HA has weak mechanical properties. Hyaluronic acid can break down quickly due to enzymes (hyaluronidase) and free radicals. To improve its durability, HA is sometimes chemically cross-linked to form a stronger version called cross-linked HA which lasts longer in the skin compared to regular HA and is often used in injectable dermal fillers.

Injecting hyaluronic acid from outside the body can be painful, have also some medical limitations, and may cause side effects. A better approach may be to focus on promoting the production of hyaluronic acid within human cells. This could lead to more effective and long-lasting hydration for the skin. A promising solution is the HA- and CLHA-based microneedling.

 

 

What Is Microneedling?

Microneedling is a skincare treatment that uses tiny needles to create small punctures in the skin. This process encourages the skin to heal and produce more collagen. Collagen is a natural protein that helps keep your skin firm and smooth. The treatment is also known as collagen induction therapy. It’s simple but effective.

Microneedling is unique because it combines the benefits of both injections and topical skin cosmetics. They are long enough to reach the dermis, but short and narrow enough to avoid irritating nerves or damaging blood vessels. The needles are usually a few hundred microns wide, with lengths ranging from 100 to 1000 microns, and tips that are 1 to 10 microns. The size and number of microneedles vary based on their intended use.

 

 

Combining Hyaluronic Acid with Microneedling

Using Hyaluronic acid in combination with microneedling delivers HA more effectively than regular topical products, and even sole microneedling. Microneedling is easy to use, causes less pain, and has fewer side effects compared to dermal fillers. Many studies have shown that microneedling with HA can help reduce wrinkles and improve skin appearance.

In case of hyaluronic acid, the deeper it goes, the better. On the other hand, microneedling alone stimulates the skin’s natural healing process, and when mixed with hyaluronic acid, it nourishes and hydrates the skin even more and supports skin repair and recovery.

Together, these treatments help reduce the appearance of fine lines, wrinkles, and scars more quickly than when used separately.

 

 

Why Hyaluronic Acid Is Preferred Over Other Ingredients

Microneedling is typically complemented with hyaluronic acid for several reasons. Here’s why it is preferred over other serums:

1. Hydration
   Hyaluronic acid draws moisture into the skin, and provides deep hydration without causing irritation. After microneedling, your skin needs intense hydration, and hyaluronic acid helps replenish moisture lost during the procedure.
2. Gentleness
   Unlike other active ingredients, hyaluronic acid is gentle and non-irritating. It’s well-tolerated by most skin types, especially post-treatment when the skin is sensitive.
3. Boosts Healing
   Hyaluronic acid supports skin repair by promoting tissue regeneration and collagen production and thus can speed up healing after microneedling.
4. Compatibility with Microneedling
   Microneedling creates tiny channels in the skin, making it easier for hyaluronic acid to penetrate deeply. It works synergistically in providing hydration and encouraging skin regeneration.
5. Non-Comedogenic
   Hyaluronic acid doesn’t clog pores. It hydrates without causing breakouts, which is important as microneedling can sometimes trigger acne or irritation if pore-clogging products are used.
6. Non-Irritating
   After microneedling, the skin is very sensitive. Many other serums, like those with retinoids or acids, may cause irritation. Hyaluronic acid is soothing and helps calm the skin down post-procedure.
7. No Risk of Overloading Skin
   Other serums with active ingredients (like Vitamin C, AHA/BHA, or peptides) can overload the skin and cause sensitivity or damage when used after microneedling. Hyaluronic acid is simple, effective, and the safest choice for recovery.

 

 

The Procedure of Microneedling and Hyaluronic Acid

1. First, the skin is cleansed thoroughly to remove dirt and oils.
2. Next, a numbing cream is applied to minimize discomfort during the treatment.
3. Then, a dermaroller or a microneedling pen with tiny needles is used to create small punctures in the skin. These channels allow for better absorption of products like hyaluronic acid.
4. After the microneedling session, hyaluronic acid is applied directly to the skin. Because the skin is now more open and receptive, the hyaluronic acid is able to deeply penetrate and hydrate the skin.

The procedure is quick, and there is little downtime. You may experience some redness, but this usually fades within a few hours.

 

 

Application of Hyaluronic Acid During or After Microneedling

In some treatments, the hyaluronic acid is massaged into the skin during the microneedling session. In others, it is applied after the treatment is complete. Both methods are effective in helping the skin absorb the hyaluronic acid. The timing depends on the type of treatment you receive, but in either case, the hyaluronic acid helps calm the skin and enhances hydration.

When applying hyaluronic acid after microneedling, it helps to lock in moisture. It also soothes the skin, reducing any irritation or redness caused by the needles. The hydration provided by hyaluronic acid helps the skin heal faster, giving you better results in a shorter time.

 

What Results Can I Expect with Microneedling and Hyaluronic Acid?

The main immediate benefit of combining hyaluronic acid with microneedling is deep hydration. After the treatment, your skin will feel refreshed, soft, and will look more even right away.

Over time, the treatment can reduce fine lines, wrinkles, and sagging. As collagen builds up, the skin becomes tighter and more elastic.

Most people begin to see noticeable improvements within a few weeks, with continued progress over several months. For optimal and lasting results, you may need to undergo multiple sessions spaced a few weeks apart, depending on your skin’s needs.

Note: Before you combine microneedling with hyaluronic acid, it’s important to speak with a skincare professional. They can assess your skin type and recommend the best approach. They may suggest using certain topical products to prepare your skin for treatment.

 

Dos and Don'ts of Using Microneedling with Hyalouranic Acid

After your microneedling session, it’s essential to follow these tips:

• Use a gentle cleanser to avoid irritating your skin after microneedling.
• Avoid harsh skincare products like exfoliants for a few days to let your skin heal properly.
• Apply hyaluronic acid to keep your skin hydrated and support the healing process.
• Avoid direct sun exposure, and Use sunscreen to protect your skin from UV damage during the healing period.
• Avoid picking at or touching the treated areas to prevent irritation or infection.
• Wait a few days before applying makeup to allow the skin to fully heal.

 

Other Alternatives to Combine with Microneedling: PRP vs. Hyaluronic Acid

Platelet-Rich Plasma (PRP)

PRP (Platelet-Rich Plasma) treatment involves extracting a small amount of your blood. After the blood is processed in a centrifuge, the platelet-rich plasma is extracted. This plasma is rich in growth factors and platelets that help promote tissue repair. The PRP is then injected into the skin or used alongside microneedling to boost results.

When applied to the skin, PRP triggers collagen production and helps repair damaged tissue. The procedure is minimally invasive, and since it uses your own blood, it carries a low risk of side effects or allergies.

 

 

Is Microneedling Better with PRP or Hyaluronic Acid?

Hyaluronic acid and PRP both offer excellent skin benefits, but they work differently. Hyaluronic acid is a hydrating substance that helps the skin retain moisture. It improves skin texture and plumpness quickly by drawing water into the skin. In contrast, PRP works by stimulating your body's natural healing and collagen production.

When comparing the two, hyaluronic acid is more suitable for immediate hydration and plumping, while PRP is better for stimulating collagen growth and improving skin texture over time. Hyaluronic acid provides quick, visible results, whereas PRP works more gradually but offers longer-lasting benefits in terms of skin quality and elasticity.

Hyaluronic acid is especially effective for people with dry or dehydrated skin. Those dealing with serious skin damage, deeper wrinkles, acne scars, or skin sagging, PRP may offer better long-term benefits.

Also, hyaluronic acid treatments tend to be more affordable compared to PRP. PRP, being a more specialized procedure, usually costs more due to the need for blood extraction, centrifugation, and the complexity of the treatment. PRP treatments may also require multiple sessions to achieve optimal results.

 

 

Other Alternatives to Combine with Hyalouranic Acid

Here are some effective alternatives to microneedling that can be paired with hyaluronic acid:

There are several effective alternatives to microneedling that can be paired with hyaluronic acid to enhance skin rejuvenation. Treatments like laser skin resurfacing, and radiofrequency (RF) therapy help improve skin texture and stimulate collagen production, making the skin more receptive to hyaluronic acid. Ultrasound therapy (Ultherapy) and microscurrent therapy promote deeper skin rejuvenation and hydration, while LED light therapy and PRP therapy accelerate healing and collagen synthesis. Dermal fillers and oxygen facials provide additional volume and hydration, while cryotherapy improve skin health and moisture retention. Stem cell therapy and collagen induction therapy (CIT) further support skin regeneration and long-term hydration, boosting the overall effects of hyaluronic acid for smoother, firmer, and more radiant skin.

 

What Areas Can Be Treated with Hyaluronic Acid?

• Face:
  • Fine lines and wrinkles, such as under the eyes, around the mouth, and on the forehead.
  • Plumping areas like the cheeks and lips for a fuller appearance.

 

• Neck and Décolletage:
  • Targets signs of aging such as fine lines and sagging.
  • Improves texture and firmness in delicate regions.

 

• Hands:
  • Enhances skin affected by sun damage, dryness, and age spots.
  • Addresses neglected areas in skincare routines.

 

• Arms:
  • Useful for improving skin texture and addressing signs of sun damage and dryness.

 

Is There Any Downtime with Microneedling and Hyaluronic Acid?

Microneedling with hyaluronic acid typically requires minimal downtime. After the treatment, you may experience some redness and mild swelling, similar to a light sunburn. This usually lasts for a few hours but should subside by the next day. Your skin may also feel dry or tight, but this is temporary.

The application of hyaluronic acid immediately after microneedling can help soothe the skin, reduce discomfort and accelerate the healing process. In general, most people can return to their normal activities the next day with no major issues.

 

 

Is There a Downside to Hyaluronic Acid and Microneedling?

While microneedling with hyaluronic acid is generally safe, there are some people who should avoid this treatment.

• Individuals with sensitive skin or skin conditions such as eczema, rosacea, or psoriasis should be cautious when considering microneedling. The treatment may irritate these conditions and cause flare-ups, leading to redness or inflammation.
• People with active acne, especially cystic acne, should also avoid microneedling. Microneedling can cause further irritation to inflamed skin and may lead to more breakouts. In these cases, it is better to wait until the acne has been treated and the skin has healed before starting microneedling.
• Those with a history of keloid scarring or other types of abnormal scarring should also avoid microneedling. This is because the healing process from microneedling could cause an overproduction of collagen, leading to the formation of keloid scars. It's important to discuss your medical history with a skincare professional before undergoing treatment to ensure it is safe for you.
• If you are pregnant, breastfeeding, or have any chronic health conditions, it is important to inform your provider before scheduling the treatment. Certain conditions may require additional precautions or make the treatment less suitable.

 

Frequently Asked Questions

1.What not to put on your face before microneedling?

Avoid retinoids, AHAs/BHAs, strong acids, and harsh exfoliants for at least 48 hours before microneedling. Ensure your skin is clean and free of irritants.

2. What products can I not use after microneedling?

 Avoid retinoids, exfoliants (AHAs, BHAs), alcohol-based products, and harsh active ingredients like Vitamin C immediately after microneedling.

3. Should I microneedle with or without serum?

 Always use a serum while microneedling to ensure smooth gliding and maximum absorption. Hyaluronic acid is the most recommended.

4. What is the best sheet mask after microneedling?

 Choose a sheet mask with soothing and hydrating ingredients like hyaluronic acid, aloe vera, or peptides. Avoid masks with alcohol or strong actives.

5. Does microneedling affect Botox or filler?

 Microneedling does not affect Botox but can interfere with fillers if done too soon after the injection. Wait 2 weeks after Botox or fillers before microneedling.

6. What cannot be used with hyaluronic acid?

 Avoid highly acidic products (like low-pH AHAs or BHAs) in the same routine to maintain hyaluronic acid's effectiveness.

7. What does too much hyaluronic acid do to your face?

 Overuse can draw moisture out of the skin in very dry conditions, leading to dehydration and irritation. Also, excessive use can cause a sticky feel, clog pores, or exacerbate dehydration if your environment lacks humidity.

 

 

References:

1. An, J. H., Lee, H. J., Yoon, M. S., & Kim, D. H. (2019). Anti-wrinkle efficacy of cross-linked hyaluronic acid-based microneedle patch with acetyl hexapeptide-8 and epidermal growth factor on Korean skin. Annals of Dermatology, 31(3), 263–270. https://doi.org/10.5021/ad.2019.31.3.263
   
   
2. Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han & Jing Han (2022) The most promising microneedle device: present and future of hyaluronic acid microneedle patch, Drug Delivery, 29:1, 3087-3110,